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Liposarcoma

Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum.They are typically large bulky tumors which tend to have multiple smaller satellites extending beyond the main confines of the tumor.

Symptoms:

Patients usually note a deep seated mass in their soft tissue. Only when the tumor is very large do symptoms of pain or functional disturbances occur.

Few other Symptoms are

· Pain

· Painful swelling

· Reduced range of motion

· Numbness

· Enlarged varicose veins

· Fatigue

· Vomiting

· Nausea

· Weight loss

· Emaciation

· Abdominal pain

· Compression of the kidney

· Compression of the ureter

Causes

Although the precise etiology of liposarcomas is not yet defined, the presumed origin likely involves terminal dedifferentiation of mesenchymal cellular components. For myxoid/round-cell liposarcomas, the TLS-CHOP oncoprotein plays a key role in tumor formation.No specific causative environmental factors have been identified because of the rarity of these tumors.

Medications

Ultrasound: Sound waves can be used to form images of the abdomen that identify the presence of a tumor. An ultrasound is performed by placing a probe on the surface of the abdomen while monitoring the image on the screen.

Magnetic resonance imaging (MRI): This is primarily a medical imaging technique used in radiology to visualize detailed internal structure and limited function of the body. MRI provides much greater contrast between the different soft tissues of the body than computed tomography (CT) does, making it especially useful in neurological (brain), musculoskeletal, cardiovascular, and oncological (cancer) imaging. Unlike CT, MRI uses no ionizing radiation.

Angiography :In this procedure contrast dyes are injected into the bloodstream and then radiographic images are taken of the area near the tumor. Angiography is sometimes used to help surgeons plan the best approach to remove the tumor.

Treatments

Radiation therapy: Radiation therapy (also called radiotherapy) is a type of local therapy. It affects cells only in the treated area. Radiation therapy is used alone for small tumors or for patients who cannot have surgery. It may be used before surgery to kill cancer cells and shrink the tumor. It also may be used after surgery to destroy cancer cells that may remain in the area.

Surgery: Physicians at Mayo Clinic typically recommend that liposarcomas be surgically removed whenever possible. Surgeons try to remove the primary cancer completely while minimizing the impact on the function and appearance of the affected part of the body. Patients who undergo surgery receive a thorough evaluation by an anesthesiologist prior to surgery.

Computed tomography (CT) :is a medical imaging method employing tomography created by computer processing. Digital geometry processing is used to generate a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation.

 

 

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